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The Gut-Brain Connection: Managing Anxiety and Depression



Have you ever had a “gut feeling” about something that turned out to be right? There’s actually some science behind that feeling in your belly. Our gut and brain are intimately connected through what’s called the gut-brain axis. What goes on in our gut sends signals to the brain that can profoundly impact our mental health. Likewise, stress and emotion can throw off the natural balance of our gut bacteria. So if we want to get to the bottom of emotional struggles like anxiety and depression, optimizing gut health is one important piece of the puzzle.


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Let me explain a bit more about how this gut-brain connection works. The vagus nerve is like a superhighway with constant two-way traffic between the gut and brain. Gut microbes interact with the vagus nerve and release key neurotransmitters like GABA, serotonin and dopamine that influence everything from mood and motivation to sleep and appetite. An imbalance in gut bacteria or inflammation in the gut triggers the vagus nerve, and those signals get sent straight to the brain, impacting function. No wonder they call the gut the “second brain!”



Now, lots of research clearly shows links between chronic GI issues like IBS or intestinal infections and poor mental health outcomes. For example, a study in the journal Microbiome found that patients with IBS were 7 times more likely to have depression than healthy folks.


The reasons behind this are complex, but include things like: 


  • Too much of the “bad” bacteria like c. difficile that drive inflammation and may even release toxins that impact the brain.

  • Leaky gut, where particles like bacteria and undigested food leak out of the intestines into the bloodstream due to damage to the gut lining. This can activate the immune system and cause brain inflammation. 

  • Nutrient deficiencies, as our gut health influences how well we absorb mood-boosting nutrients like magnesium, zinc, and vitamin D.

  • Impaired communication between the gut and brain via the vagus nerve and other pathways.


We also can’t leave out how an overgrowth of the fungus candida in the gut has also been associated with increased anxiety. A study in Microbiome found higher levels of candida in the stools of people with anxiety disorders compared to healthy controls. Candida disrupts the gut microbiome balance and can release toxins that impact the brain. Addressing a candida overgrowth may help alleviate anxiety symptoms.


The good news is there are many effective ways we can start healing from both ends – body and mind. I always tell my clients, "let’s start with the gut and build from there."


  • Load up on prebiotic fibers from greens, beans, nuts and seeds to nourish our good gut bugs.

  • Eat fermented foods like unsweetened yogurt, kefir, kimchi and kombucha to add more beneficial bacteria into the mix.

  • Consider taking a high-quality probiotic supplement as well. 

  • Reduce stress through daily practices like yoga, meditation, deep breathing, or talk therapy.

  • Go for walks outdoors to boost gut microbial diversity.

  • Get enough sleep, as research shows lack of sleep negatively impacts gut health.


These positive steps help balance gut bacteria, heal the gut lining, reduce inflammation, and send the right signals back to the brain.



While optimizing gut health through diet and lifestyle can help manage symptoms, it may be beneficial to seek support through counseling, therapy, or other integrative modalities.


Remember, a healthy gut equals a healthy mind. By taking care of our whole body, we can give our gut and our brain what they need to find balance. And give ourselves the best chance for healing and lasting wellness.




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functional health

Jennifer Bray

Nutritional Therapy Practitioner

Master Restorative Wellness Practitioner

Certified in Gut Healing, Hormone Healing, Comprehensive Blood Panels, Autoimmune Diseases, and Toxins

National Association of Nutrition Professionals

I am ready to take my health back!
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